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Crohns Colitis 17 , 12071216 (2023)

In an experimental model of abdominal aortic aneurysm, topiramate markedly downregulated pro-inflammatory M1 macrophage activity, reduced the expression of TNF-, IL-1, and matrix metalloproteinase-9, and promoted a phenotypic shift of macrophages from M1 to M2, thereby mitigating pro-inflammatory activity and enhancing tissue repair processes (Attia et al., 2023)

These suggest that while plasma selenium status may not be directly linked to the overall risk of prostate cancer, there is an association between elevated selenium levels and a reduced risk of high-grade prostate cancer

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